منابع مشابه
Valproic acid and immune thrombocytopenia.
During the course of a prospective serial study over a period of one year, findings compatible with immune-mediated thrombocytolysis accompanied the administration of valproic acid in about half of 45 children with epilepsy. Thrombocytopenia occurred in 15 and neutropenia in 12 patients, but was transient and self-limiting in each. The association is probably one of cause and effect, and it may...
متن کاملValproic acid and thrombocytopenia: cross-sectional study.
OBJECTIVE To investigate the relationship between platelet count and serum valproic acid level, age, duration of valproic acid therapy, and polytherapy, and to determine the clinical significance of thrombocytopenia associated with high-dosage valproic acid therapy. DESIGN Cross-sectional study. SETTING Residential unit for neurologically impaired children and paediatric out-patient clinic,...
متن کاملVALPROIC ACID- valproic acid solution Par Pharmaceutical ----------
WARNINGS: LIFE THREATENING ADVERSE REACTIONS See full prescribing information for complete boxed warning. Hepato toxicity, including fatalities, usually during first 6 months o f treatment. Children under the age of two years and patients with mitochondrial disorders are at higher risk. Monitor patients c losely, and perform serum liver testing prior to therapy and at frequent intervals thereaf...
متن کاملThe Risk of Thrombocytopenia During Valproic Acid Therapy: A Critical Summary of Available Clinical Data
Valproate is an effective anti-epileptic and mood stabilizer drug, but its prescription may be complicated by the development of thrombocytopenia. The purpose of the present manuscript is to provide a critical overview about the risk of thrombocytopenia during treatment with valproate. A search of the main database sources has been conducted to identify relevant papers about the topic. In the s...
متن کاملValproic acid and pubertas praecox
Precocious puberty refers to the appearance of physical and hormonal signs of pubertal development at an earlier age than is considered normal. In girls, the telltale signs of precocious puberty include any of the following symptoms before 7 or 8 years of age: breast development, pubic or underarm hair development, rapid height growth a growth "spurt", onset of menstruation, acne and "mature" b...
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ژورنال
عنوان ژورنال: Pediatric Neurology Briefs
سال: 1996
ISSN: 2166-6482,1043-3155
DOI: 10.15844/pedneurbriefs-10-8-13